Chinese Companies Are Selling Vapes With Chemicals Potentially More Potent Than Nicotine

Earlier this year, I picked up a rather unfortunate habit: vaping. More specifically, I started smoking flavored vapes manufactured in China’s so-called “Vape Valley” and sold throughout the United States.

Flavored nicotine vapes are largely illegal in the US, yet convenience stores and tobacco shops across the country have generated billions of dollars in sales from these products in recent years, despite periodic law enforcement seizures and efforts by the Food and Drug Administration to keep them off the market. More recently, Chinese manufacturers have found a new way to sidestep the law, escaping regulatory oversight altogether.

Like many people, I assumed the only addictive chemical in these products was synthetic nicotine, which vape manufacturers have used for years to avoid FDA oversight. But after Congress closed that loophole in 2022—expanding regulation beyond tobacco-derived nicotine—Chinese manufactures began filling their vapes with little-studied chemicals that mimic nicotine's effects, known as nicotine analogs.

Because current regulations still narrowly define what counts as nicotine, Chinese companies have been able to sell nicotine analog vapes in the US without having to worry about federal tobacco rules, which generally require companies to submit new products to the FDA for scientific review before they can be legally marketed.

“This is just like whack-a-mole, these companies will do everything they can to circumvent regulation,” says Robert Jackler, an emeritus professor of head and neck surgery at Stanford University and the founder of an interdisciplinary research group studying the impacts of tobacco advertising.

The effects of nicotine analogs on humans haven't been extensively researched, but animal studies have found that one of the most popular variants, 6-methyl-nicotine, could be more potent and addictive than regular nicotine. Vapes containing nicotine analogs may also expose users to other mysterious chemicals. One 2024 study found that some manufacturers were selling nicotine analog vapes that contained additional unlabeled ingredients, including artificial sweeteners and cooling agents with unknown inhalation risks. “What's on the label has very little relationship to what's in it,” says Jackler.

Researchers first documented the emergence of vapes containing 6-methyl-nicotine and other nicotine analogs in the US market about three years ago. But the chemical compounds themselves are nothing new—tobacco companies have been researching them since as far back as the 1970s.

A 2005 review of millions of previously secret internal industry documents found Big Tobacco had long explored nicotine-like compounds as replacements for nicotine, in part because they believed they could help circumvent potential regulation.